Cytokeratin (Dako Omnis)

Clone AE1/AE3

Reacts with the 65-67, 64, 59, 58, 56.5, 56, 54, 52, 50, 48 and 40 kDa cytokeratins. The antibody labels keratinized and corneal epidermis, stratified squamous epithelia of internal organs, stratified epithelia, hyperproliferative keratinocytes, and simple epithelia. The antibody is useful aid for classification of tumors of epithelial origin as well as undifferentiated carcinomas.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.

Specifications


Application	Formalin HIER
Clone	AE1/AE3
Code Number	GA053
Immunogen	Human epidermal callus (1). See package insert for reference(s).
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN₃. Clone: AE1/AE3. Isotype: IgG1, kappa.
Solutions	Dako Omnis
Species	Mouse Anti-Human
Specificity	AE1/AE3 is a cocktail of two monoclonal antibodies that were obtained by immunizing mice with human callus keratins (2). AE1/AE3 has been shown to identify the majority of human cytokeratins and thus may be used as a tool for the positive IHC identification of cells of simple and stratified epithelial origin (1,2,4). Antibody AE1 immunoreacts with an antigenic determinant present on most of the subfamily A cytokeratins, including cytokeratins with Moll's designation (4) 10, 13, 14, 15 16 and 19 (MWs of 56.5, 54', 50, 50', 48 and 40 kDa, respectively) but not on Nos. 12, 17 and 18 (55, 47 and 45 kDa) (4). Antibody AE3 reacts with an antigenic determinant shared by the subfamily B cytokeratins including Nos. 1 and 2, 3, 4, 5, 6, 7 and 8 (MWs of 65, 67, 64, 59, 58, 56, 54 and 52 kDa, respectively) (5). See package insert for reference(s).

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Cytokeratin (Dako Omnis)

Product Details

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