This monoclonal rabbit antibody reacts with cyclin D1, a 36 kDa protein encoded by the CCND1 (bcl-1) gene located on chromosome 11q13. Cyclin D1 is part of the cell cycle regulation and oncogenic transformation in mammalian cells. The cyclin-dependent kinases, CDK4 and CDK6, are associated with and activated by cyclin D1 thereby promoting G1 phase progression by retinoblastoma protein phosphorylating along with related proteins. Antibodies to cyclin D1 are a useful aid for classification of mantle cell lymphomas in the context of lymphoid tumors (1-2).
This product is not available for purchase by the general public.
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Synthetic peptide corresponding to residues near the C-terminus of human cyclin D1.
Ready-to-use monoclonal rabbit antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Autostainer Link 48
In Western blotting of MCF7 cells lysates the antibody labels a major band of approximately 36 kD, corresponding to the expected molecular weight of cyclin D1.
1. Donnellan R, Chetty R. Cyclin D1 and human neoplasia. J Clin Pathol: Mol Pathol 1998,51:1-7. 2. Falini B, Martelli MP, Tiacci E, Ascani S, Thiede C, Pileri SA. Immunohistochemical surrogates for genetic alterations of CCND1, PML, ALK, and NPM1 genes in lymphomas and acute myeloid leukemia. Best Practice & Research Clin Haematol 2010:23:417-31.