COX-2 (Concentrate)

The cyclooxygenase (COX) enzymes are critical in the biosynthesis of prostaglandins from arachidonic acid. COX-2 is a 70 kDa enzyme that is responsible for prostaglandin synthesis at the site of inflammation and is readily induced in response to cell activation by cytokines, growth factors and tumor promoters. Results aid in the classification of a variety of malignancies, including colorectal adenocarcinoma, a subset of breast adenocarcinomas and adjacent ductal carcinoma in situ, lung adenocarcinoma, esophageal squamous cell carcinoma and squamous adenocarcinoma, malignant melanoma, and subsets of ovarian carcinoma and prostate carcinoma.