Normal appendix
Chromogranin A (Dako Omnis)
Antibodies to chromogranin A have been shown to aid in the classification of neuroendocrine tumors (4–11).
- Monoclonal Mouse Anti-Human
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Product Details
Features
- Optimized staining performance of both high and low-expression structures.
- Crisp and clear staining with no background.
- Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis family of instruments.
- Consistent, uniform staining with excellent morphology enabled by dynamic gap staining technology on the Dako Omnis family of instruments.
- Defined, tested, and approved staining performance for all FLEX RTU antibodies through collaboration with leading international pathology experts.
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Literature
- Technical Overviews
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Immunohistochemical Staining Methods - Education Guide, Sixth Edition
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.
- Technical Overviews
- English
- 30 Nov 2021
- 27.05 MB
Support
- Instructions for Use
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Featured References
- Product Description References
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1.Kruggel, W.; O'Connor, D. T.; Lewis, R. V. The Amino Terminal Sequences of Bovine and Human Chromogranin A and Secretory Protein I Are Identical. Biochem. Biophys. Res. Commun. 1985, 127 (1), 380-383. DOI: 10.1016/S0006-291X(85)80170-4.
2.Portela-Gomes, G. M. Chromogranin A Immunoreactivity in Neuroendocrine Cells in the Human Gastrointestinal Tract and Pancreas. Adv. Exp. Med. Biol. 2000, 482, 193-203. DOI: 10.1007/0-306-46837-9_15.
3.Lloyd, R. V.; Cano, M.; Rosa, P.; Hille, A.; Huttner, W. B. Distribution of Chromogranin A and Secretogranin I (Chromogranin B) in Neuroendocrine Cells and Tumors. Am. J. Pathol. 1988, 130 (2), 296-304.
4.Aslan, D.; Gulbahce, H.; Pambuccian, S.; Manivel, J.; Jessurun, J. Ki-67 Immunoreactivity in the Differential Diagnosis of Pulmonary Neuroendocrine Neoplasms in Specimens with Extensive Crush Artifact. Am. J. Clin. Pathol. 2005, 123 (6), 874-878. DOI: 10.1309/QYV05VGEGKUL2RTT.
5.Annaratone, L.; Medico, E.; Rangel, N.; Castellano, I.; Marchiò, C.; Sapino, A.; Bussolati, G. Search for Neuro-Endocrine Markers (Chromogranin A, Synaptophysin and VGF) in Breast Cancers. An Integrated Approach Using Immunohistochemistry and Gene Expression Profiling. Endocr. Pathol. 2014, 25 (3), 219-228. DOI: 10.1007/s12022-013-9277-4.
6.Duregon, E.; Parasiliti-Caprino, M.; Orlando, G.; Ferrero, A. P.; Bollati, M.; Pedrosa, R.; Kumar, D.; Giraudo, G.; Pasini, B.; Ghigo, E.; et al. From Tissue Architecture to Genetic Signature: Artificial Intelligence-Based Analysis of Reticulin Framework and Clinical Variables Predicts Molecular Cluster in Paragangliomas. Endocr. Pathol. 2026, 37 (1), 8. DOI: 10.1007/s12022-026-09904-4.
7.Bordi, P.; Tiseo, M.; Barbieri, F.; Bavieri, M.; Sartori, G.; Marchetti, A.; Buttitta, F.; Bortesi, B.; Ambrosini-Spaltro, A.; Gnetti, L.; et al. Gene Mutations in Small-Cell Lung Cancer (SCLC): Results of a Panel of 6 Genes in a Cohort of Italian Patients. Lung Cancer 2014, 86 (3), 324-328. DOI: 10.1016/j.lungcan.2014.10.002.
8.Mamilla, D.; Manukyan, I.; Fetsch, P.; Pacak, K.; Miettinen, M. Immunohistochemical Distinction of Paragangliomas from Epithelial Neuroendocrine Tumors: Gangliocytic Duodenal and Cauda Equina Paragangliomas Align with Epithelial Neuroendocrine Tumors. Hum. Pathol. 2020, 103, 72-82. DOI: 10.1016/j.humpath.2020.07.010.
9.Juhlin, C.; Zedenius, J.; Höög, A. Clinical Routine Application of the Second-Generation Neuroendocrine Markers ISL1, INSM1, and Secretagogin in Neuroendocrine Neoplasia: Staining Outcomes and Potential Clues for Determining Tumor Origin. Endocr. Pathol. 2020, 31 (4), 401-410. DOI: 10.1007/s12022-020-09645-y.
10.Rodriguez, E.; Fite, J.; Chowsilpa, S.; Maleki, Z. Insulinoma-Associated Protein 1 Immunostaining on Cytology Specimens: An Institutional Experience. Hum. Pathol. 2019, 85, 128-135.
11.Şincu, M. C.; Cocuz, I. G.; Tinca, A. C.; Niculescu, R.; Sabău, A.-H.; Chiorean, D. M.; Morariu, S. H.; Cotoi, O. S. Neuroendocrine Tumors (NETs): Experience of a Single Center. Rom. J. Morphol. Embryol. 2021, 62 (2), 457-463. DOI: 10.47162/RJME.62.2.11.
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