Cdx2, a human gene homologous to the Drosophila caudal-type homeobox gene, encodes a transcription factor, which is involved in proliferation and differentiation of intestinal epithelial cells. The CDX2 protein is widely expressed in intestinal epithelium from the duodenum to the rectum. Scattered expression has been reported in pancreatic ductules, while no expression has been observed in other normal tissues tested. Results aid in the classification of both primary and metastatic tumors of the gastrointestinal tract, including carcinoids.
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Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Recombinant human CDX2 corresponding to amino acids 1-165.
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
In Western blotting of Caco-2 lysate the antibody labels a 37 kDa and 40 kDa band corresponding to the expected molecular weight of CDX2 (3). Additional bands at 17 kDa and 19 kDa were also labeled by the antibody.