Cdx2, a human gene homologous to the Drosophila caudal-type homeobox gene, encodes a transcription factor, which is involved in proliferation and differentiation of intestinal epithelial cells. The CDX2 protein is widely expressed in intestinal epithelium from the duodenum to the rectum. Scattered expression has been reported in pancreatic ductules, while no expression has been observed in other normal tissues tested. Results aid in the classification of both primary and metastatic tumors of the gastrointestinal tract, including carcinoids.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
DAK-CDX2
Code Number
IR080
Immunogen
Recombinant human CDX2 corresponding to amino acids 1-165.
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Autostainer Link 48
Species
Mouse Anti-Human
Specificity
In Western blotting of Caco-2 lysate the antibody labels a 37 kDa and 40 kDa band corresponding to the expected molecular weight of CDX2 (3). Additional bands at 17 kDa and 19 kDa were also labeled by the antibody.