Cdx2, a human gene homologous to the Drosophila caudal-type homeobox gene, encodes a transcription factor, which is involved in proliferation and differentiation of intestinal epithelial cells. The CDX2 protein is widely expressed in intestinal epithelium from the duodenum to the rectum. Scattered expression has been reported in pancreatic ductules, while no expression has been observed in other normal tissues tested. Results aid in the classification of both primary and metastatic tumors of the gastrointestinal tract, including carcinoids.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Frozen
Formalin
HIER
Clone
DAK-CDX2
Code Number
M3636
Immunogen
Recombinant human CDX2 corresponding to amino acids 1-165.
Isotype
IgG1, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant (containing fetal bovine serum) dialyzed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 0.015 mol/L sodium azide.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
In Western blotting of Caco-2 lysate the antibody labels a 37 kDa and 40 kDa band corresponding to the expected molecular weight of CDX2 (2, 12). Additional bands at 17 kDa and 19 kDa were also labeled by the antibody (12). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.