CD8 is a 68 kDa transmembrane glycoprotein expressed as a heterodimer by a majority of thymocytes, and by class I major histocompatibility complex restricted, mature, suppressor/cytotoxic T cells. The antibody is a useful aid for classification of cytotoxic/suppressor T-cell lymphomas.
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Synthetic peptide corresponding to the 13 C-terminal amino acids of cytoplasmic domain of human CD8α coupled to thyroglobulin (1). See package insert for reference(s).
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN3.
SDS-PAGE analysis of immunoprecipitates formed between lysates of 125I-labeled human T lymphoblasts and the antibody shows reaction primarily with a 32 kDa polypeptide corresponding to CD8α (1). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.