CD79α is encoded by the mb-1 gene and was previously called Igα. The antibody recognizes an extracellular epitope expressed on the CD79α molecule. Results aid in the classification of B-cell neoplasms in routine biopsy material. In addition to the expression in B cells, CD79α has been found to be co-expressed with CD3 in 10% of cases of T-lymphoblastic leukemia/lymphoma. Antibodies to CD79α may also be a useful aid for classification of Hodgkin's disease.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Specifications
Application
Formalin
HIER
Clone
JCB117
Code Number
GA621
Immunogen
Recombinant protein containing part of the extracellular portion of the human CD79α glycoprotein (1). See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Dako Omnis
Species
Mouse Anti-Human
Specificity
Anti-Human CD79α, clone JCB117, was clustered as anti-CD79α at the Sixth International Workshop and Conference on Human Leucocyte Differentiation Antigens (4). In Western blotting of Ramos B-cell lysate, the antibody labels a band corresponding to CD79α under reducing conditions, and a band corresponding to CD79αß under non-reducing conditions (1). SDS-PAGE analysis of immunoprecipitates formed between the antibody and 125I-labeled, mildly denatured, and reduced lysate of Ramos B cells, shows weak reaction with a 43 kDa polypeptide corresponding to CD79α. See package insert for reference(s).
1. Mason DY, Cordell JL, Brown MH, Borst J, Jones M, Pulford K, et al. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples. Blood 1995,86:1453-9. 2. Pilozzi E, Pulford K, Jones M, Muller-Hermelink HK, Falini B, Ralfkiaer E, et al. Co-expression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma. J Pathol 1998,186:140-3. 3. Chu PG, Arber DA. CD79: a review. Appl Immunohistochem Mol Morphol 2001,9:97-106