Tonsil

CD68 (Autostainer Link 48)

Clone KP1

Labels human monocytes, macrophages and myeloid cells. It is of value for demonstrating reactive macrophages in a wide variety of normal and pathological specimens and for the identification of myeloid and histiocytic cells. Results aid in the classification of neoplasms of myeloid and macrophage/monocyte origin.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	KP1
Code Number	IR609
Immunogen	Lysosomal fraction of human lung macrophages (4). See package insert for reference(s).
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Autostainer Link 48
Species	Mouse Anti-Human
Specificity	Anti-Human CD68, clone KP1, was clustered as anti-CD68 at the Fourth International Workshop and Conference on Human Leucocyte Differentiation Antigens (5). In Western blotting of extracts of lung, spleen and U937 cells, diffuse 110, 70 and 40 kDa bands were detected when using reducing conditions. Under non-reducing conditions the spleen extract showed an additional 220 kDa band (4). SDS-PAGE analysis of immunoprecipitates formed between the antibody and ¹²⁵I-labeled lysates from human spleen with B-cell lymphoma rich in macrophages shows reaction with a 110 kDa polypeptide, corresponding to CD68 (4). See package insert for reference(s).

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