Platelet glycoprotein IIIa (GpIIIa) is identical to the β3-integrin subunit, which can associate with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is a useful aid for classification of megakaryoblastic leukemia.
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Phytohemagglutinin (PHA)-stimulated peripheral blood cells (6). See package insert for reference(s).
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN3.
Anti-CD61, Y2/51, was included in the Fourth International Workshop and Conference on Human Leucocyte Differentiation Antigens and studies by a number of laboratories confirmed its reactivity with CD61 (7). Anti-CD61, Y2/51, labels platelets in peripheral blood and bone marrow and it also reacts with megakaryocytes (6). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.