Hodgkin Lymphoma

CD57 (Dako Omnis)

Clone TB01

CD57 is expressed by subsets of NK cells and CD8+ lymphocytes, and by a small percentage of CD4+/CD45R0+ T lymphocytes in lymph node germinal centres. The number of CD57+ cells increases in some pathologies characterized by an imbalance of CD4/CD8 lymphocytes. Normal neuroectodermal cells and striated muscle also express CD57. Antibodies to CD57 have been shown to aid in classification of T-cell large granular lymphocyte disorders, oligodendrogliomas and neuroendocrine tumors, and inclassification of lymphocyte predominant Hodgkin's lymphoma.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.

Specifications


Application	Formalin HIER
Clone	TB01
Code Number	GA647
Immunogen	A pool of neuroblastoma cell lines (1). See package insert for reference(s).
Isotype	IgM, kappa
Reagent Provided	Ready-to-use monoclonal antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN₃.
Solutions	Dako Omnis
Species	Mouse Anti-Human
Specificity	Anti-Human CD57, Clone TB01, was clustered as anti-CD57 at the 6th International Workshop and Conference on Human Leucocyte Differentiation Antigens (5). In immunocytochemistry, the antibody labels T-cells in unfixed human endometrial tissue (8). The epitope defined by Anti-Human CD57, Clone TB01, is neuraminidase- and bromelain-sensitive but trypsin-resistant (1). See package insert for reference(s).

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CD57 (Dako Omnis)

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