CD45 is a transmembrane glycoprotein expressed on most nucleated cells of hematopoetic origin. On human leucocytes, five different isoforms of CD45 have been identified, named ABC, AB, BC, B and 0. Clone 2B11 reacts with all known isotypes of the CD45 family and clone PD7/26 has been clustered as anti-CD45RB. The antibody is a useful aid for classification of lymphoid neoplasms.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Specifications
Application
Formalin
HIER
Clone
2B11 + PD7/26
Code Number
GA751
Immunogen
2B11: Isolated neoplastic cells from a case of T-cell lymphoma/leukemia (1). PD7/26: Human peripheral blood lymphocytes maintained in T-cell growth factor (1). See package insert for reference(s).
Isotype
IgG1, kappa and IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Dako Omnis
Species
Mouse Anti-Human
Specificity
Anti-CD45 is a mixture of two monoclonal antibodies, clones 2B11 and PD7/26, directed against different epitopes. Clone 2B11 was clustered as anti-CD45 at the Third International Workshop and Conference on Human Leucocyte Differentiation Antigens and reacts with all the known isotypes of the CD45 family (6). Clone PD7/26 was clustered as anti-CD45RB at the Fifth International Workshop and Conference on Human Leucocyte Differentiation Antigens (7). See package insert for reference(s).