CD4 is a transmembrane glycoprotein, expressed on normal thymocytes, T-helper cells, majority of mature peripheral T cells, and a subset of suppressor or cytotoxic T cells. CD4 is not found on immature thymocytes. The antibody is a useful aid for classification of anaplastic large cell lymphomas, unspecified peripheral T-cell lymphomas and mycosis fungoides.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
4B12
Code Number
IR649
Immunogen
Recombinant protein corresponding to the external domain of the CD4 molecule.
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Autostainer Link 48
Species
Mouse Anti-Human
Specificity
In tonsil, the crowded and isolated T-helper cells show a moderate to strong staining reaction. In liver, the Kupffer and endothelial cells of the sinusoids show a weak to moderate staining reaction.