CD34 is a single-chain transmembrane protein of approximately 116 kDa, expressed on immature hematopoietic stem/progenitor cells, capillary endothelial cells, embryonic fibroblasts and rare glial cells in nervous tissue. CD34 is a stage-specific, rather than a lineage-specific, leucocyte differentiation antigen. The antibody is a useful aid for classificaction of vascular and lymphatic tumors and for the subclassification of leukemias.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
QBEnd 10
Code Number
IR632
Immunogen
Endothelial cell membranes obtained as vesicles from human placenta (2, 3).
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
Solutions
Autostainer Link 48
Species
Mouse Anti-Human
Specificity
Anti-CD34, QBEnd 10, was included in the Fourth and Fifth International Workshops and Conferences on Human Leucocyte Differentiation Antigens, and studies by different laboratories confirmed its reactivity with the CD34 antigen (2, 3) and the class II epitope (3). In formalin-fixed, paraffin embedded tonsil sections the antibody labels endothelial cells. See package insert for reference(s).