CD30 is a transmembrane cytokine receptor belonging to the tumor necrosis factor (TNF) receptor superfamily. Mature CD30 has a molecular mass of 120 kDa. The intracellular part of CD30 possesses kinase activity, indicating a role in differentation and/or proliferation. CD30 expression is found on Hodgkin's and Reed-Sternberg cells, and on activated B and T lymphocytes. CD30 is also expressed by embryonal carcinoma cells. This antibody is a useful aid for the classification of anaplastic large cell lymphoma.
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Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Co cell line established from a patient with Hodgkin's disease of T-cell lineage (1, 6). See package insert for reference(s).
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Anti-Human CD30, clone Ber-H2, was clustered as anti-CD30 at the Fourth International Workshop and Conference on Human Leucocyte Differentiation Antigens (7).
SDS-PAGE analysis of immunoprecipitates formed between lysate of 125I-labeled COS cells transfected with cDNA encoding CD30 and the antibody shows reaction with a 120 kDa protein corresponding to CD30. Mock-transfected COS cells were negative. The epitope recognized by the antibody is located between amino acid residues 112 and 412 (8).
The antibody labels cell lines derived from Hodgkin's disease, L428, L540, L591, Co, Ho and KM-H2; HTLV-1 transfected T-cell lines, Hut-102 and MT-2; EBV-transformed B-cell lines (non-Burkitt), B95-8 (monkey), BJA-B and Cess; and the myeloid cell line, K 562 (1).