Lung adenocarcinoma

CD246, ALK Protein (Dako Omnis)

Clone OTI1A4

Anaplastic lymphoma kinase (ALK) protein is a receptor tyrosine kinase that is expressed in normal neuronal cells types. Genetic alterations in ALK (fusions, amplifications and mutations) are reported in a variety of tumor types including non-small cell lung carcinoma (NSCLC). The OTI1A4 antibody detects a chimeric ALK protein in subtypes of NSCLC containing an EML4-ALK fusion gene. Results aid in the classification of ALK-positive lung cancer subgroups.

Primary Antibodies

Features

Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis

Specifications


Application	Formalin HIER
Clone	OTI1A4
Code Number	GA785
Immunogen	Human recombinant protein fragment corresponding to amino acids 1300-1620 of human ALK (NP_004295) produced in E.coli.
Isotype	IgG2b
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Dako Omnis
Specialty	Lung
Species	Mouse Anti-Human
Specificity	In Western blotting of H2228 and A549 cell line extracts, the antibody labels a band at 90 kDa corresponding to the expected molecular weight of ALK.

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Featured References

Product Description References: 1. Qi M, Li Y, Liu J, et al. Morphologic features of carcinomas with recurrent gene fusions. Advances in anatomic pathology. 2012;19(6):417-24.
2. Kim H, Xu X, Yoo SB, et al. Discordance between anaplastic lymphoma kinase status in primary non-small-cell lung cancers and their corresponding metastases. Histopathology. 2012.
3. Wang Z, Zhang X, Bai H, et al. EML4-ALK rearrangement and its clinical significance in Chinese patients with advanced non-small cell lung cancer. Oncology. 2012;83(5):248-56.
4. Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561-6.
5. Thunnissen E, Bubendorf L, Dietel M, et al. EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations. Virchows Archiv: an international journal of pathology. 2012;461(3):245-57.

CD246, ALK Protein (Dako Omnis)

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