Follicular lymphoma (grade III)

CD21 (Autostainer Link 48)

Clone 1F8

CD21 is a transmembrane glycoprotein belonging to a family of complement regulatory proteins. It is expressed by follicular dendritic cells (FDC) and mature B cells, as well as by several types of epithelial cells. The antibody is a useful aid for classification of malignant lymphomas. Furthermore, the antibody may be useful for the subclassification of mature T-cell lymphoma of the angioimmunoblastic subtype.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	1F8
Code Number	IR608
Immunogen	CD21 preparation purified from human tonsils to 60% purity (4). See package insert for reference(s).
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Autostainer Link 48
Species	Mouse Anti-Human
Specificity	In Western blotting of the immunogen, the antibody labels a band of 145 kDa, corresponding to CD21. The epitope recognized by the antibody is located within a 72 kDa C3d-binding fragment (4). The antibody labels cells or cell lines known to express CD21 (Raji, NC 37, tonsil cells), whereas no labeling is observed in the CD21-negative Jurkat cells (T-cell line) and human erythrocytes (4). See package insert for reference(s).

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Featured References

Product Description References: 1. Bagdi E, Krenacs L, Krenacs T, Miller K, Isaacson PG. Follicular dendritic cells in reactive and neoplastic lymphoid tissues: a reevaluation of staining patterns of CD21, CD23, and CD35 antibodies in paraffin sections after wet heat-induced epitope retrieval. Appl Immunohistochem Mol Morphol 2001,9:117-24.
2. Troxell ML, Schwartz EJ, van de Rijn M, Ross DT, Warnke RA, Higgins JP, et al. Follicular dendritic cell immunohistochemical markers in angioimmunoblastic T-cell lymphoma. Appl Immunohistochem Mol Morphol 2005,13:297-303.

CD21 (Autostainer Link 48)

Product Details

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