Thymoma

CD1a (Autostainer Link 48)

Clone 010

CD1a, a member of the CD1 antigen family, is a non-polymorphic MHC class I-related cell surface glycoprotein expressed in association with β₂-microglobulin. Langerhans' cells, interdigitating dendritic cells and medullary thymocytes in thymic medulla are labeled by anti-CD1a. This antibody is a useful aid for classification of thymomas and malignancies of T-cell precursors.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	010
Code Number	IR069
Immunogen	Human thymus cells.
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Autostainer Link 48
Species	Mouse Anti-Human
Specificity	Anti-Human CD1a, clone O10, was clustered as anti-CD1a at the 4th International Workshop and Conference on Human Leucocyte Differentiation Antigens (2). Clone O10 has been shown to immunoprecipitate labeled CD1a from thymus cell lysate and from Langerhans' cell-enriched epidermal cell lysate (2). In the latter, the antibody strongly precipitated the native CD1a molecule (49 kDa molecular weight) and ß₂.-microglobulin (12 kDa molecular weight) but not the trypsin-cleaved CD1a molecule (27 kDa molecular weight) (2). In IHC, the antibody has been demonstrated to react with the CD1a cell surface glycoprotein expressed on cortical thymocytes, Langerhans' cells, and interdigitating dendritic (reticulum) cells in frozen and formalin-fixed, paraffin-embedded (FFPE) tissues (1, 2). See package insert for reference(s).

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CD1a (Autostainer Link 48)

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