CD19 is the broadest lineage-specific surface marker for B cells. CD19 is present on the surface of virtually all B lymphocytes, including early B-progenitor cells, but it is lost upon terminal differentiation to plasma cells. CD19 is also expressed on follicular dendritic cells (1). Results aid in the classification of B-lineage leukemias and lymphomas.
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years’ experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
HIER
Clone
LE-CD19
Immunogen
Synthetic peptide comprising the C-terminus of CD19.
Isotype
IgG1, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant (containing fetal bovine serum) dialyzed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 0.015 mol/L sodium azide.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
In Western blotting of lysed Raji cells (Burkitt's lymphoma) and Jurkat cells (T-ALL) under reduced conditions, the antibody labels a band of 95 kDa in Raji cells, corresponding to CD19, whereas no band is observed in Jurkat cells.
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.
