Myeloma

CD138 (Autostainer Link 48)

Clone MI15

CD138, syndecan-1, is a transmembrane proteoglycan with a main cellular expression in stratified and simple epithelia. Within the hemopoietic system, CD138 is mainly confined to late stages of B-cell differentiation. CD138 expression is reduced during malignant transformation of various epithelia, and CD138 is rapidly shed by myeloma cells entering into apoptosis. This antibody is a useful aid for classification of multiple myeloma. Anti-CD138 may also be useful for the subclassification of diffuse large B-cell lymphomas.

Monoclonal Mouse Anti-Human

Features

Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.

Specifications


Application	Formalin HIER
Clone	MI15
Code Number	IR642
Immunogen	A mixture of U266 and XG-1 human myeloma cell lines (2, 8). See package insert for reference(s).
Isotype	IgG1, kappa
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Autostainer Link 48
Species	Mouse Anti-Human
Specificity	Anti-Human CD138, clone MI15, was clustered as anti-CD138 at the 6th International Workshop and Conference on Human Leucocyte Differentiation Antigens (1). The epitope recognized by anti-CD138, MI15, is found within the ectodomain (extracellular part) of the CD138 core protein. Blocking experiments have revealed that the epitope recognized by MI15 seems to be partly overlapping the epitope recognized by another antibody to CD138, clone B-B4 (1, 5). Anti-CD138, MI15, reacts strongly with CD138 expressed by multiple myeloma-derived cell lines, such as U266 and XG-1 (8). See package insert for reference(s).

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CD138 (Autostainer Link 48)

Product Details

Atlas of Controls

View supported Instructions For Use documents

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