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CD10 (Dako Omnis)

Clone DAK-CD10

CD10 is a cell surface metallopeptidase, expressed on early lymphoid progenitor cells and on a small subset of immature B cells in bone marrow, but is lost as the cells reach maturation. CD10 is, however, re-expressed on proliferating B cells and mature neutrophils. The DAK-CD10 antibody may be a useful aid for classification of Burkitt lymphoma, follicular lymphoma, diffuse large B-cell lymphoma and renal cell carcinoma clear cell type.

Primary Antibodies

Features

Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis

Specifications


Application	Formalin HIER
Clone	DAK-CD10
Code Number	GA786
Immunogen	Synthetic peptide within the extracellular domain of human CD10.
Isotype	IgG1
Reagent Provided	Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions	Dako Omnis
Specialty	Lymphoma
Species	Mouse Anti-Human
Specificity	In Western blotting of Raji cell lysate, the antibody labels a band at 90-100 kDa, corresponding to the expected molecular weight of CD10.

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Featured References

Product Description References: 1. Ordi J, Romagosa C, Tavassoli FA, et al. CD10 expression in epithelial tissue and tumors of the gynecologic tract. A useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Am J Surg Pathol 2003;27:178-86.
2. Béné MC, Faure GC and Group D’Etude Immunologique des Luecémies. CD10 in acute leukemias. Haematologica 1997;82:205-10.
3. Leong AS-Y, Cooper K, Leong FJW-M. CD10. Manual of diagnostic antibodies for immunohistology. London: Greenwich medical media; 2003. p. 77-8.
4. Le Gouill S, Talmant P, Touzeau C, et al. The clinical presentation and prognosis of diffuse large B-cell lymphoma with t(14:18) and 8q24/c-MYC rearrangement. The hematology journal 2007;92:1335-42.
5. Kaufmann O, Flath B, Späth-Schwalbe, et al. Immunohistochemical detection of CD10 with monoclonal antibody 56C6 on paraffin sections. Am J Clin Pathol 1999;11:117-22.
6. Chu PG, Chang KL, Weiss LM, et al. Immunohistochemical detection of CD10 in paraffin sections of hematopoietic neoplasms. App Imm & Mol Morphol. 2000;8:257-62.
7. Chen CC, Raikow RB, Sonmez-Alpan E, et al. Classification of small B-cell lymphoid neoplasms using a paraffin section immunohistochemical panel. App Imm & Mol Morphol 2000;8:1-11.

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CD10 (Dako Omnis)

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