CD10 is a cell surface metallopeptidase, expressed on early lymphoid progenitor cells and on a small subset of immature B cells in bone marrow, but is lost as the cells reach maturation. CD10 is, however, re-expressed on proliferating B cells and mature neutrophils. Various non-lymphoid cells, including bile canaliculi and renal glomerular and tubular epithelial cells are also CD10-positive. The antibody may be a useful aid for classification of Burkitt's lymphoma, follicular lymphoma except grade III, precursor B-cell acute lymphoblastic leukemia, and clear cell renal cell carcinoma. Futhermore, CD10 antibodies may also be a useful aid in the subclassification of the mature T-cell neoplasia subtype and angioimmunoblastic T-cell lymphoma. Anti-CD10, Clone 56C6, is well-suited for use on formalin-fixed tissue sections.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Dako Omnis and the dynamic gap staining technology provides a consistent, uniform staining with excellent morphology
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Dako Omnis
The staining performance of all FLEX RTU antibodies has been defined, tested and approved through collaboration with leading, international pathology experts.
Specifications
Application
Formalin
HIER
Clone
56C6
Code Number
GA648
Immunogen
Recombinant fusion protein corresponding to the external domain of the CD10 glycoprotein.
Isotype
IgG1
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Dako Omnis
Species
Mouse Anti-Human
Specificity
In Western blotting of placental cell lysate, the antibody labels a 93 kDa band corresponding to CD10 (11). See package insert for reference(s).
1. Attygalle A, Al-Jehani R, Diss TC, Munson P, Liu H, Du M-Q, et al. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD10. Blood 2002,99:627-33.