Calretinin is a 32 kDa member of the superfamily of calcium-binding proteins. It is abundantly expressed in central and peripheral neural tissues, particularly in the retina and in the neurons of the sensory pathways, and calretinin may play an important role in the survival of nerve cells during disturbances in calcium homeostasis. Calretinin is also expressed by mesothelial cells, and the antibody is a useful aid for classification of malignant mesotheliomas of the epithelial type.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
Enzyme/HIER
Clone
DAK-Calret 1
Code Number
M7245
Immunogen
From the human malignant mesothelioma cell line, Mero-41 (6, 7), the gene encoding calretinin was amplified by PCR and expressed as recombinant protein in E. coli. . The purified protein was used for immunization. See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Monoclonal mouse antibody provided in liquid form as cell culture supernatant dialysed against 0.05 mol/L Tris-HCl, pH 7.2, and containing 15 mmol/L NaN3.
Solutions
Concentrate
Species
Mouse Anti-Human
Specificity
In immunocytochemistry, the antibody specifically labels calretinin.
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