Calretinin is a 32 kDa member of the superfamily of calcium-binding proteins. It is abundantly expressed in central and peripheral neural tissues, particularly in the retina and in the neurons of the sensory pathways, and calretinin may play an important role in the survival of nerve cells during disturbances in calcium homeostasis. Calretinin is also expressed by mesothelial cells, and the antibody is a useful aid for classification of malignant mesotheliomas of the epithelial type.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
DAK-Calret 1
Code Number
IR627
Immunogen
From the human malignant mesothelioma cell line, Mero-41 (6, 7), the gene encoding calretinin was amplified by PCR and expressed as recombinant protein in E. coli. . The purified protein was used for immunization. See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Autostainer Link 48
Species
Mouse Anti-Human
Specificity
In immunohistochemistry, the antibody specifically labels calretinin.