Caldesmon is a smooth muscle-specific protein involved in the regulation of smooth muscle contraction. The antibody recognizes the high molecular mass variant of caldesmon (h-caldesmon) and does not react with the non-muscle variant.
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Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Crude human uterus extract (1). See package insert for reference(s).
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L NaN3.
Autostainer Link 48
Two closely related variants of human caldesmon have been identified which differ in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120-150 kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70-80 kDa) is found in non-muscle tissue and cells. Neither of the two variants have been detected in skeletal muscle (3). Monoclonal anti-caldesmon, h-CD, recognizes only the 150 kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin (1). See package insert for reference(s).