A synthetic peptide, coupled to keyhole limpet hemocyanin, has been used for immunization. The peptide represents part of the predicted 185 kDa oncoprotein encoded by ERBB2, also termed HER2 or NEU. The antibody recognizes an epitope on the cytoplasmic part of the cell membrane-bound c-erbB-2 oncoprotein. Overexpression of c-erbB-2 oncoprotein has been found in 25-30% of human breast carcinomas.
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Product Details
Features
Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years experience ensuring quality and innovation in antibodies and reagents
Specifications
Application
Formalin
HIER
Clone
Polyclonal
Code Number
A0485
Immunogen
Synthetic human c-erbB-2 oncoprotein peptide from the intracytoplasmic part of the c-erbB-2 oncoprotein.
Reagent Provided
Affinity-isolated rabbit antibody purified by using immobilized c-erbB-2 oncoprotein peptide and provided in liquid form in 0.05 mol/L Tris-HCl, 0.1 mol/L NaCl, 15 mmol/L NaN3.
Solutions
Concentrate
Species
Rabbit Anti-Human
Specificity
The antibody labels an intracellular domain of c-erbB2 oncoprotein.
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.