Beta-catenin is an 88 kDa multifunctional protein playing an essential role in cell-cell adhesion by binding to the transmembrane protein, cadherin. Beta-catenin is also involved in the regulation of gene expression as a mediator of the Wnt signaling pathway. The expression and intracellular localization of beta-catenin is altered in many types of cancers.
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Recombinant C-terminal β-catenin fusion protein (6). See package insert for reference(s).
Monoclonal mouse antibody provided in liquid form as tissue culture supernatant in 0.05 mol/L Tris-HCl, pH 7.2 and 0.015 mol/L sodium azide. This product contains stabilizing protein.
Anti-beta-catenin, clone β-catenin-1 recognized human β-catenin protein in Western blots of human epithelial A431 cells and mouse β-catenin in blots of mouse fibroblast NIH/3T3 cells. No cross-reactivity with α and γ-catenin was observed (6). See package insert for reference(s).
The focus of the sixth edition of the IHC Guidebook is to provide a comprehensive immunohistochemistry (IHC) resource for lab managers, lab technicians, learning pathologists, and students from around the world.