Beta-catenin is an 88 kDa multifunctional protein playing an essential role in cell-cell adhesion by binding to the transmembrane protein, cadherin. Beta-catenin is also involved in the regulation of gene expression as a mediator of the Wnt signaling pathway. The expression and intracellular localization of beta-catenin is altered in many types of cancers.
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Product Details
Features
Optimized staining performance of both high and low-expression structures
Crisp and clear staining with no background
Optimal laboratory efficiency with ready-to-use antibodies on Autostainer Link 48
The staining performance of all antibodies has been defined, tested and approved through collaboration with leading international pathologists. Check the Atlas of Stains - a guide to diagnostic accuracy.
Specifications
Application
Formalin
HIER
Clone
β-Catenin-1
Code Number
IR702
Immunogen
Recombinant C-terminal ß-catenin fusion protein (6). See package insert for reference(s).
Isotype
IgG1, kappa
Reagent Provided
Ready-to-use monoclonal mouse antibody provided in liquid form in a buffer containing stabilizing protein and 0.015 mol/L sodium azide.
Solutions
Autostainer Link 48
Species
Mouse Anti-Human
Specificity
In Western blotting of human epithelial A431 cells the antibody labels a band corresponding to human β-catenin protein. No cross-reactivity with α and γ-catenin was observed (6). See package insert for reference(s).