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BCL6 Protein (Autostainer Link 48)

Follicular lymphoma

BCL6 Protein (Autostainer Link 48)

Clone PG-B6p

The BCL6 gene encodes a 706 amino acid nuclear protein of the Kruppel-type zinc finger protein. It is rearranged in about 30% of diffuse large B-cell lymphomas, and is expressed predominantly in normal germinal centre B cells and related lymphomas . The antibody is a useful aid for classification of follicular lymphomas, diffuse large B-cell lymphomas, Burkitt's lymphomas, and nodular, lymphocyte-predominance Hodgkin's lymphoma. The BCL6 antibody, together with BCL2 antibody, is also a useful aid in classification of mantle cell lymphomas, and nodular, lymphocyte-predominance Hodgkin's lymphoma. BCL6 protein is not expressed in B-CLL, hairy cell leukemia, mantle cell and marginal-zone derived lymphomas (1, 2).

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