PL-SCX for Prep to Process
PL-SCX strong cation-exchange materials are extremely hydrophilic and are designed for purification of biomolecules. The materials are totally polymeric and are chemically and thermally stable over a full range of HPLC conditions.
The strong cation-exchange functionalities, covalently linked to a chemically stable polymer, facilitate cation-exchange purifications over a wider pH range. This stability can be exploited for column sanitation and clean-up, and also enables the use of denaturing conditions and stabilizing/solubilizing agents for the purification of target compounds, as encountered in the purification of synthetic oligonucleotides with self-complementary sequences.