AdvanceBio 2-AB Labeled Glycan Standards and Libraries
AdvanceBio 2-AB labeled N-glycan standards and libraries are commonly used as qualitative standards for LC/FLD and LC/MS. 2-AB standards come pre-labeled with 2-AB, ready to reconstitute and inject.
The sialic acid linkage of the sialylated glycans within the 2-AB library are α(2,6) rather than the α(2,3) linkage seen in e.g. CHO glycoproteins.
The sialic acid linkage of the sialylated glycans within the 2-AB library are α(2,6) rather than the α(2,3) linkage seen in e.g. CHO glycoproteins.
- Glycobiology Standards & Libraries
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Product Details
Features
2-AB labeled glycan standards are commonly used as qualitative standards for LC/FLD or LC/MS.
How It Works
Literature
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Complete N-Glycan Workflow Solutions
Agilent offers tools and support for every step of your glycan sample preparation and analysis workflow.
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- 09 Oct 2024
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Glycan Peak Assignment Tool for Improved Accuracy in N-Glycan HILIC/FLD Analysis
Agilent Glycan Peak Assignment Tool for improved accuracy in N-glycan analysis with separations using the AdvanceBio Amide HILIC column.
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- 30 May 2024
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2-AB Labeled Glycans Frequently Asked Question (FAQ)
Frequently asked questions for 2-AB Labeled Glycans
Featured References
- Publications
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- CFG: Functional Glycomics Gateway [Internet]. Symbol and Text Nomenclature for Representation of Glycan Structure. Nomenclature Committee, Consortium for Functional Glycomics; [2012; cited 2015 Oct 6]. Available from: http://glycomics.scripps.edu/CFGnomenclature.pdf
- Lee EU, Roth J, Paulson JC. Alteration of terminal glycosylation sequences on N-linked oligosaccharides of Chinese hamster ovary cells by expression of beta-galactoside alpha 2,6-sialyltransferase. J Biol Chem. 1989 Aug 15;264(23):13848-55.
- Anthony RM, Nimmerjahn F, Ashline DJ, Reinhold VN, Paulson JC, Ravetch JV. Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc. Science. 2008 Apr 18;320(5874):373-6.
- Raymond C, Robotham A, Spearman M, Butler M, Kelly J, Durocher Y. Production of α2,6-sialylated IgG1 in CHO cells. MAbs. 2015;7(3):571-83.
- GlycoBase 3.2.4. [Internet]. Blackrock, Ireland: National Institute for Bioprocessing Research and Training (NIBRT); c2012. All Collections including digests (93); [cited 2016 Apr 12]. Available from: https://glycobase.nibrt.ie/glycobase/browse_glycans.action
- Szekrényes Á, Park SS, Cosgrave E, Jones A, Haxo T, Kimzey M, Pourkaveh S, Szabó Z, Sosic Z, Feng P, Sejwal P, Dent K, Michels D, Freckleton G, Qian J, Lancaster C, Duffy T, Schwartz M, Luo JK, van Dyck J, Leung PK, Olajos M, Kowle R, Gao K, Wang W, Wegstein J, Tep S, Domokos A, Váradi C, Guttman A. Multi-site N-Glycan mapping study 2: UHPLC. Electrophoresis. 2018 Apr;39(7):998-1005.
- GlycoBase 3.2.4. [Internet]. Blackrock, Ireland: National Institute for Bioprocessing Research and Training (NIBRT); c2012. Guide to the abbreviations used to identify 2AB labelled N-glycans; [cited 2016 Apr 19]. Available from: www.glycobase.nibrt.ie/glycobase/documents/abbreviations.pdf
- Harvey DJ, Merry AH, Royle L, Campbell MP, Dwek RA, Rudd PM. Proposal for a standard system for drawing structural diagrams of N- and O-linked carbohydrates and related compounds. Proteomics. 2009 Aug;9(15):3796-801
- Ceroni A, Maass K, Geyer H, Geyer R, Dell A, Haslam SM. GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans. J Proteome Res. 2008 Apr;7(4):1650-9.
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