2-AB Labeled Glycans
Agilent 2-AB labeled N-glycan standards and libraries are commonly used as qualitative standards for LC/FLD and LC/MS. 2-AB standards come pre-labeled with 2-AB, ready to reconstitute and inject.
The sialic acid linkage of the sialylated glycans within the 2-AB library are α(2,6) rather than the α(2,3) linkage seen in e.g. CHO glycoproteins.
The sialic acid linkage of the sialylated glycans within the 2-AB library are α(2,6) rather than the α(2,3) linkage seen in e.g. CHO glycoproteins.
- Glycobiology Standards & Libraries
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2-AB labeled glycan standards are commonly used as qualitative standards for LC/FLD or LC/MS.
Literature
- Application Notes
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Development of a Rapid 2-AB Sample Preparation Workflow for N-Glycans
The characterization of N-glycans is essential to the development of biotherapeutics.
- Application Notes
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- 08 Jan 2021
- 601.12 KB
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2-AB Labeled Glycans Frequently Asked Question (FAQ)
Frequently asked questions for 2-AB Labeled Glycans
Featured References
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News
The Importance of Glycan Analysis and Characterization for Biopharma
Professor Michael Butler, head of the National Institute for Bioprocessing Research and Training (NIBRT) Cell Technology Group (CTG), explains that the characterisation and analysis of glycans is important for the biopharma sector as it can help in the development of therapeutic agents, such as monoclonal antibodies and other recombinant proteins. These are used in therapies in a range of serious conditions including cancer, inflammatory diseases, and cardiovascular diseases. The mechanism of action depends upon their strong affinity to molecular targets associated with disease.
- Drug Discovery World (DDW)
- 10 Oct 2022
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