1290 Infinity III Fluorescence Detector

Features

Superior fluorescence sensitivity: Achieve Raman S/N > 2,500 and dark noise > 30,000 S/N for cleaner baselines, stronger peaks, and confident trace-level detection.
UHPLC-ready peak integrity: Protect narrow UHPLC peaks with low-dispersion 2 and 13 µL flow cells, high acquisition speed, and fast switching for reliable integration.
More evidence per injection: Confirm in one run with up to 5 Ex/Em pairs, online 200 to 800 nm spectra, and <250 ms wavelength switching for fewer follow-up injections.
Fast wavelength switching: Maintain selectivity in fast methods with <250 ms switching, including ~120 ms switching at Rs ~1.8 in the PAH workflow.
Wide linear dynamic range: Support quantitation across >5 orders of magnitude, with LDR up to 6 orders and typical linearity >0.999 in application testing.
Easy front-access service: Minimize downtime with quick, front-access, tool-free exchange of lamp (with a statistically qualified 2000 h guaranteed lamp lifetime), flow cell, and window when maintenance is needed.
Broad pH compatibility: Support method flexibility across chemistries with broad pH tolerance from 1.0 to 12.5 for biopharma and routine QC workflows.
Broad software support: Supports OpenLab CDS and ChemStation workflows, with Chromeleon, Empower, and MassHunter compatibility extending per roadmap.
High-energy optical design: Use a 150 W Hg-Xe lamp and high-performance optics to deliver strong excitation energy, stable output, and low-noise signal quality.
Biopharma-ready flexibility: Bio-compatible, low-adsorption wetted materials and UHPLC-optimized fluidics minimize carryover and metal-ion interactions – ideal for peptides, glycans, oligonucleotides.

How It Works

Applications

Literature

Application Notes

Sensitive and Repeatable Analysis of InstantPC-labeled N-Glycans from Human Immunoglobulin G

This application note demonstrates that the Agilent 1290 Infinity III Bio LC System with an Agilent 1290 Infinity III Fluorescence Detector (FLD) delivers reliable, high-confidence N-glycan profiles under UHPLC conditions.

Application Notes
English
18 Mar 2026
558.70 KB
PDF

Sensitive Detection of PAHs Using the Agilent 1290 Infinity III Fluorescence Detector

This application note describes the results obtained for the measurement of a multi-compound PAH sample by means of the Agilent 1290 Infinity III Fluorescence Detector.

Application Notes
English
10 Mar 2026
1.45 MB
PDF

Sensitive Detection of Aflatoxins by the Agilent 1290 Infinity III Fluorescence Detector

This application note shows the analysis of aflatoxins on the Agilent 1290 Infinity III FLD at highest sensitivity, enabling LODs and LOQs under UHPLC conditions.

Application Notes
English
13 Feb 2026
929.42 KB
PDF

Support

Site Preparation Checklists

Agilent InfinityLab LC Series Site Preparation Checklist

InfinityLab LC Series Site Preparation Checklist (Rev. D.04)

Site Preparation Checklists
English
13 Mar 2026
379.31 KB
PDF

User Manuals

Featured

Product Details

Sensitive and Repeatable Analysis of InstantPC-labeled N-Glycans from Human Immunoglobulin G

Sensitive Detection of PAHs Using the Agilent 1290 Infinity III Fluorescence Detector

Sensitive Detection of Aflatoxins by the Agilent 1290 Infinity III Fluorescence Detector

Agilent InfinityLab LC Series Site Preparation Checklist

Videos