Non-small cell lung cancer

PD-L1 (Concentrate)

CE-IVD

Clone 22C3

Code M3653

This antibody labels PD-L1 protein in formalin-fixed, paraffin-embedded tissue. It is indicated as an aid in the assessment of PD-L1 expression in tumors. The balance between T cell activation, tolerance and immunopathology is regulated by inhibitory signals delivered by programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2.

Please note that Monoclonal Mouse Anti-Human PD-L1, Clone 22C3 is not available in all countries. Contact us to hear about availability in your country.

Reg. Status: CE-IVD

Monoclonal Mouse Anti-Human

Features

Excellent specificity
High lot to lot consistency
Optimized for immunohistochemistry (IHC) with validated protocols
Certified manufacturing facilities guarantee full quality control
More than 50 years’ experience ensuring quality and innovation in antibodies and reagents

Specifications


Application	Formalin HIER
Clone	22C3
Code Number	M3653
Immunogen	Human extracellular domain of PD-L1 (Phe19-Thr239) fused to a human IgG1 fragment (R&D Systems Catalogue No. 156-B7-100) (5). See package insert for reference(s).
Isotype	IgG1, kappa
Reagent Provided	Monoclonal mouse antibody provided in liquid form in 0.05 mol/L Tris-HCl, 0.015 mol/L sodium azide, 1% bovine serum albumin, pH 7.2.
Solutions	Concentrate
Species	Mouse Anti-Human
Specificity	In Western blotting of recombinant human PD-L1 protein, Monoclonal Mouse Anti-Human PD-L1, Clone 22C3 labels a band corresponding to ~40 kDa (5). See package insert for reference(s).

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Featured References

Product Description References: 1. Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo Jr. VA, Lombard LA, et al. Cloning of B7-2, a cTLA4 counter-receptor that costimulates human T cell proliferation. Science 1993,262:909-11.
2. Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008,26:677-704.

PD-L1 (Concentrate)

Product Details

Immunohistochemical Staining Methods - Education Guide, Sixth Edition

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