Anti-human CD45RA antibodies. These single-color reagents are of value to the study of T lymphocytes and B cells.
CD45 is a transmembrane glycoprotein expressed on most nucleated cells of haematopoietic origin. On human leucocytes, five different isoforms of CD45, named ABC, AB, BC, B and 0, have been identified. Antibodies to CD45RA recognize the extracellular A domain in the two isoforms, ABC and AB. Various leucocytes express characteristic CD45 isoforms, and T cells differentially express CD45 isoforms at various stages of their development and activation.
Further information and references to relevant literature are available in the products Instructions For Use.