Anti-human CD41 antibodies. These single-color reagents are of value to the study of platelets and platelet precursors.
CD41 is the α subunit of the CD41/CD61 complex (GPllb-llla), a calcium-dependent, non-covalently associated heterodimer. CD41 is a 135 kDa molecule, consisting of 2 peptides: a 120 kDa α chain and a 23 kDa β chain. The α chain and the β chain are linked by a single disulphide bond. The α chain contains four calcium-bindingsites and is entirely extracellular, while the β chain has extracellular, transmembrane and cytoplasmic domains. The CD41/CD61 complex appears early in megakaryocyte maturation.
Further information and references to relevant literature are available in the products Instructions For Use.