Anti-human CD11b antibodies. These single-color reagents are of value to the study of leucocytes CD11b is the 165 kDa a-chain of the Mac-1 complex. The molecule, also called CR3, functions as a cell surface receptor for the C3bi complement fragment. There is evidence that CD11b can bind fibrinogen in addition to C3bi. Two binding sites have now been reported, one recognizing lipopolysaccharide, and the other protein ligands containing the arg-gly-asp sequence. Binding of the coagulation factor X has also been suggested as an additional receptor role of CD11b. Besides the C3bi receptor, this protein family contains two other members, CD11a and CD11c.
References to relevant literature are available in the products Instructions For Use.