CD10 is a 100 kDa transmembrane protein. CD10 is expressed on immature T and B-precursor cells but is lost as the cells reach maturation. In lymphoid malignancies, CD10 is expressed in acute lymphoblastic leukemia (ALL) arising from precursor B cells, but is also observed in a proportion of T-cell ALL. Additionally, it is expressed selectively in mature B-cell leukemia, including multiple myeloma, and in lymphomas.
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