
xCELLigence Immunotherapy Kits
Continuous monitoring of the potency of immune cell-mediated killing of target liquid cancer cells under physiological relevant conditions provides real-time kinetics analysis.
- RTCA Reagents, Kits & Accessories
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Product Details
- Flexible assays use label free methods for more physiological assay conditions, eliminating labeling or secondary assays
- Real-time quantitative monitoring of both fast (hours) and slow (days) killing kinetics
- Sensitive assays capable of evaluating low effector cell to target cell ratios that are physiologically relevant
- Simple workflow that requires only the addition of effector cells to target cells in the presence or absence of antibodies and minimal sample handling with homogeneous assay
Cellular Impedance Explained
The functional unit of a cellular impedance assay is a set of gold microelectrodes fused to the bottom surface of a microtiter plate well. When submersed in an electrically conductive solution (such as buffer or standard tissue culture medium), the application of an electric potential across these electrodes causes electrons to exit the negative terminal, pass through bulk solution, and then deposit onto the positive terminal to complete the circuit.
Learn More- Application Notes
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Evaluating Functional Potency of Immunotherapies Targeting Liquid Tumors
Describes use of a tethering approach to immobilize liquid tumor cell lines on to the surface of gold biosensors embedded in an Agilent E-Plate.
- Application Notes
- English
- 27 Jun 2025
- 686.86 KB
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Agilent xCELLigence RTCA Instrumentation Supports Potency Assay Development in Recent FDA Approval
Agilent xCELLigence Real-Time Cell Analysis (RTCA) technology supports the testing of accuracy and reliability in AUCATZYL, a recently approved CAR T therapy by Autolus Therapeutics. The xCELLigence RTCA technology supported the development and implementation of the potency assay. By providing precise and reliable cell analysis capabilities, Agilent supported Autolus's efforts in establishing robust analytical methods.
- 15 Jul 2025