
xCELLigence RTCA HT - High Throughput Model
The HT model can run a 384-well electronic microplate (E-Plate 384), which is ideal for high-throughput screening experiments. Integrate up to 4 instruments controlled by a single control unit for a total of 1,536 wells to meet high throughput sample screening needs. The RTCA HT model can be used as a single instrument on a standard lab bench or integrated into a multi-instrument high-throughput workflow with automated liquid handling.
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Product Details
- xCELLigence RTCA HT model can run one 384-well E-plate, with the ability to integrate up to 4 instruments for a total of 1,536 wells
- Measure cell health, viability, or response to treatments with high sensitivity, accuracy, and reproducibility
- Obtain continuous data at high temporal resolution (from seconds to days), with non-invasive and label-free real-time impedance technology
- Easy workflow allows users to simply add cells to E-plates and begin kinetic measurements at physiological conditions, with minimal hands-on time
- Ideal for high throughput screening of therapeutic antibodies, drug compounds, and cytotoxicity.
Cellular Impedance Explained
The functional unit of a cellular impedance assay is a set of gold microelectrodes fused to the bottom surface of a microtiter plate well. When submersed in an electrically conductive solution (such as buffer or standard tissue culture medium), the application of an electric potential across these electrodes causes electrons to exit the negative terminal, pass through bulk solution, and then deposit onto the positive terminal to complete the circuit.
Learn More- Application Notes
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Evaluating Functional Potency of Immunotherapies Targeting Tumors of B Cell Origin
Describes use of a tethering approach to immobilize liquid tumor cell lines on to the surface of gold biosensors embedded in an Agilent E-Plate.
- Application Notes
- English
- 03 Jun 2022
- 1.10 MB
High-Throughput GPCR Assay Development
This application note demonstrates how the xCELLigence system can run GPCR assays without expressing additional reporter proteins.
- Application Notes
- English
- 12 Feb 2021
- 1.80 MB
A New Way to Monitor Virus-Mediated Cytopathogenicity
This application note describes the experimental setup for assessing vesicular stomatitis virus-mediated cytotoxicity of Vero E6 cells and HEK 293 cells using an xCELLigence instrument.
- Application Notes
- English
- 12 Feb 2021
- 358.59 KB
Label-Free Assay for NK Cell‑Mediated Cytolysis
In this application note, a series of experiments demonstrate how the xCELLigence RTCA system can be applied to quantitatively monitor NK cell‑mediated cytolysis without labeling the target cells.
- Application Notes
- English
- 12 Feb 2021
- 699.12 KB
Dynamic Monitoring of Receptor Tyrosine Kinase Activation in Living Cells
This application note highlights the development and utility of an alternative receptor tyrosine kinase assay that uses the impedance‑based xCELLigence system.
- Application Notes
- English
- 12 Feb 2021
- 1.58 MB
Dynamic Monitoring of G-Protein‑Coupled Receptor Activation in Living Cells
In this application note, a series of experiments demonstrates how the xCELLigence system may be used to monitor functional activation of GPCRs in living cells.
- Application Notes
- English
- 12 Feb 2021
- 1.07 MB
Dynamic Monitoring of Cell Adhesion and Spreading
In this application note, a series of experiments is described to demonstrate that the xCELLigence system is suitable for monitoring cell adhesion and spreading.
- Application Notes
- English
- 12 Feb 2021
- 1007.33 KB
Real-Time and Dynamic Monitoring of Cell Proliferation and Viability for Adherent Cells
This application note shows experiments that were conducted using xCELLigence instruments to assess cell proliferation and drug interaction with different cell lines.
- Application Notes
- English
- 19 Aug 2020
- 1.00 MB
Cancer Immunotherapy
A collection of studies showing how xCELLigence RTCA technology can be used in cancer immunotherapy research.
- Application Notes
- English
- 06 Jul 2020
- 10.12 MB
Vaccine and Virology Applications
A collection of studies showing the benefits of xCELLigence RTCA assays over traditional assays. Antiviral drugs, virucides, neutralizing antibodies and other applications are examined.
- Application Notes
- English
- 02 Jul 2020
- 4.37 MB
- Brochures
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E-Plate Coating User Guide
A guide for coating E-Plates.
- User Manuals
- English
- 21 Aug 2020
- 120.50 KB