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xCELLigence RTCA HT-BioTek BioSpa8 – Screening Model
xCELLigence Real-Time Cell Analysis uses impedance-based biosensors to obtain non-invasive, label-free measurements, continuously monitoring cell health, behavior, and function with high accuracy, sensitivity, and reproducibility. Integrating the BioSpa 8 Automated Incubator with the xCELLigence RTCA HT model enables live cell analysis of up to eight 384-well E-plates (a total of 3,072 wells) to meet high throughput sample screening needs.
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Product Details
- The xCELLigence RTCA HT instrument with BioTek BioSpa 8 automated incubator enables live cell analysis up to eight 384-well E-plates (a total of 3,072 wells) with non-invasive and label-free real-time impedance technology.
- Kinetic measurement of cell health, viability, or response to treatments with high sensitivity, accuracy, and reproducibility, provides a continuous flow of real-time data. The information gained from real-time live cell analysis goes far beyond end-point measurements.
- Automated workflow allows users to simply add cells to E-Plates 384 and begin kinetic measurements at physiological conditions. The BioSpa8 Robotic Arm transfers E-Plate 384 from the incubator to the xCELLigence RTCA HT Station. Multiple E-Plates 384 are processed while unattended, saving time in the lab.
- Critical physiological conditions are controlled and maintained in the BioSpa8 incubator to ensure assay success. Temperature and CO2/O2 control, plus humidity monitoring in the BioSpa facilitate live cell processes, and the cradle of the RTCA HT unit is temperature-controlled, for minimal disruption of the cells. The software continuously records environmental conditions.
- Small footprint saves benchtop space
- User-friendly RTCA software Pro HT-BioSpa enables simple assay setup (scheduling) for both single and multiple users, real-time data visualization, and powerful data analysis.
- Ideal for high throughput screening of therapeutic antibodies, drug compounds, and cytotoxicity.
- Typical applications include Compound-mediated cytotoxicity assay; Viral-mediated cytopathic effect (CPE); Neutralizing antibody screening; Antiviral drug screening; Immune cell potency assay; Antibody-dependent cell-mediated cytotoxicity (ADCC) assays.
- Application Notes
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xCELLigence Portfolio Cancer Immunotherapy Handbook
Recently updated Cancer Immunotherapy Handbook featuring the latest high impact xCELLigence publications and newly released supporting information.
- Application Notes
- English
- 10 Mar 2023
- 10.21 MB
Evaluating Functional Potency of Immunotherapies Targeting Tumors of B Cell Origin
Describes use of a tethering approach to immobilize liquid tumor cell lines on to the surface of gold biosensors embedded in an Agilent E-Plate.
- Application Notes
- English
- 03 Jun 2022
- 1.10 MB
A New Way to Monitor Virus-Mediated Cytopathogenicity
This application note describes the experimental setup for assessing vesicular stomatitis virus-mediated cytotoxicity of Vero E6 cells and HEK 293 cells using an xCELLigence instrument.
- Application Notes
- English
- 12 Feb 2021
- 358.59 KB
Label-Free Assay for NK Cell‑Mediated Cytolysis
In this application note, a series of experiments demonstrate how the xCELLigence RTCA system can be applied to quantitatively monitor NK cell‑mediated cytolysis without labeling the target cells.
- Application Notes
- English
- 12 Feb 2021
- 699.12 KB
Vaccine and Virology Applications
A collection of studies showing the benefits of xCELLigence RTCA assays over traditional assays. Antiviral drugs, virucides, neutralizing antibodies and other applications are examined.
- Application Notes
- English
- 02 Jul 2020
- 4.37 MB
Tumor Cell Killing by T Cells
An assay workflow demonstration measuring cytotoxic T lymphocyte-mediated destruction of tumor cells and the corresponding secretion of cytokines using an Agilent xCELLigence and NovoCyte flow cytometer instrument.
- Application Notes
- English
- 02 Jul 2020
- 601.08 KB
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Agilent Wins Scientists’ Choice Award for Best New Drug Discovery & Development Product of 2023
The xCELLigence RTCA HT-BioTek BioSpa 8 integrates label-free, real-time live cell analysis of up to eight 384-well plates with automated incubation. The system expands high-throughput screening capabilities for viral-mediated cytopathic effects (CPE), neutralizing antibodies, antibody-dependent cytotoxicity (ADCC), and compound-mediated cytotoxicity.
- 12 Mar 2024