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New Agilent ProPulse System – the small footprint, powerful NMR solution for pharmaceutical research

By Krish Krishnamurthy
Agilent Applications, Nuclear Magnetic Resonance Applications Fellow

The need for structural analysis in pharmaceutical research and development is fundamental, and often demands high-quality Nuclear Magnetic Resonance (NMR) data on challenging samples. The system used to generate these critical results must be powerful, reliable, and easy-to-use.

The new Agilent ProPulse NMR System combines our robust NMR hardware and elegant VnmrJ 4.1 software in a complete NMR system solution. The ProPulse system provides a broad range of new features created to simplify and improve NMR experiments, while helping researchers better understand their findings.

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Figure 1. Data shows the standard 1D (blue) and the PS1D (red) spectra of a 20 m molar strychnine sample in CDCl3.

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Figure 2. Powerful Agilent VnmrJ increases productivity by enabling complex NMR experiments to be run easier than ever before.

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Figure 3. The power to create variations from a single experiment and combine them into one protocol-button.

Fully automated from sample to spectrum

The Agilent ProPulse NMR System delivers the highest quality data, providing unmatched speed and reliability from an ultra-compact footprint. The extensive experimental library found in VnmrJ software, coupled with robust and linear ProPulse hardware, ensures the best possible data through an automated, intuitive workflow. Powerful pulse sequences, such as band-selective 1D and 2D experiments, and PS1D (PureShift 1D), as well as advanced techniques, including non-uniform sampling (NUS) and NMR in fully protonated solvents, are all standard and fully automated. Figure 1 captures the power of a broadband homonuclear decoupling experiment that results in simple, and easily interpreted, spectra as the basis for field independent database generation.

Simplify your workflow and get high-quality data

Powerful, user-focused Agilent VnmrJ software helps to generate results quicker than ever before by enabling complex NMR experiments to be run with ease. Compared to traditional NMR workflows, VnmrJ increases productivity by reducing the amount of work required to get high-quality data (Figure 2).

Accelerated results with sample to spectrum customization

Accelerating pharmaceutical research and development requires flexibility, speed and unambiguous results, despite evolving questions and problems, and the complexity of multiple teams working on them. Fast and truly reliable task-oriented results depend on the seamless customizability of a robust, user-friendly hardware platform. The Agilent ProPulse NMR System lets users customize default experiment protocols to suit their unique needs and combine default or custom experiment protocols to generate a new study – all with the click of a button (Figure 3).

The new Agilent ProPulse NMR System – simply better

The Agilent ProPulse NMR System delivers the highest quality data from all customized workflows. It offers unrivaled simplicity for tailoring experimental setup, optimization, and data collection. This system brings the power of NMR to researchers of all types and skill levels. With the Agilent ProPulse NMR System you can expect:

• Highest quality data: From an ultra-compact footprint
• Confidence in results: Agilent VeriPulse keeps the system optimized and proves it
• Sample to spectrum: Fully customizable and fully automated
• Spectrum to spreadsheet: Automated by Complete Reduction to Amplitude and Frequency Table (CRAFT)
• Unrivaled ease-of-use and reliability: Helps you put the focus on answers

Agilent is committed to improving the entire NMR user experience. See how Agilent brings true ease-of-use to high-performance NMR in this video overview of the Agilent ProPulse NMR System. Read all about the Agilent ProPulse NMR System and discover the complete line of Agilent NMR solutions  that can be used to analyze both small- and large-molecule compounds in research and industrial applications. 

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