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Dietary supplements and their raw materials are diverse, from an extract in a tablet to a tea packet or oil bottle in the kitchen. Producers and regulators must ensure that active compounds are at levels expected. Authenticity testing is also needed especially where it goes beyond the active compounds which can be spiked into non-authentic products. Geographic origin, freshness and production-type can affect health benefits and also require testing. LC and GC methods focus on known compounds of importance with many outlined by reference bodies like IOC, ISO, and USP. UHPLC is now speeding up testing and improving selectivity. FTIR provides even faster identity tests where applicable and is often referenced by USP for assessment of active components. It's speed is complimented by a reduced need for sample preparation and it's suitability for portable testing. Fingerprinting using mass spectrometry and spectroscopy can deliver a more comprehensive authenticity test and can also address commodities without established markers. New markers can be detected at low levels and identified ensuring they are not a passing contamination. Finding new markers of difference, needs statistical software to process spectral data from many samples. Agilent's Mass Profiler Professional takes data directly from Agilent systems to achieve this.
Featured Literature

Sample Prep for Trace Analysis of Adulterants in Erectile Dysfunction Dietary Supplements

Two sample preparation techniques were explored for the analysis of adulterants in erectile dysfunction dietary supplements using LC/MS/MS.

Fast analysis of fat soluble vitamins using the Agilent 1290 Infinity LC and ZORBAX RRHT and RRHD 1.8 μm columns

The Agilent 1290 Infinity LC has significant capabilities for a wide range of HPLC and UHPLC applications. With a broader power range (that is, the combination of pressure and

Excellent Separation of Ginseng Root Constituents by HPLC with ELSD

HPLC with ELSD analysis and separation of ginseng root constituents for identification and quantification of ginsenosides.

Featured Training & Events

Improved LC-MS/MS Pesticide Multiresidue Analysis using Triggered MRM and On-Line Dilution

This webinar will discuss development, optimization and performance of a large LC-MS/MS pesticide multiresidue method for separation of about 450 analytes within 10 minutes.