Dr. Meike Romer discusses why transmission Raman spectroscopy is ideal for content uniformity, how it works in conjunction with established liquid chromatography (LC) methods, and the approach that led to the implementation of TRS systems for content uniformity testing at Grünenthal Pharma.
The analysis of 10 pharmaceutical tablets for their content uniformity takes only several minutes, as compared to one day turnaround time when using a traditional HPLC method.
Method development using TRS100 for material identification and quantitative assay is generally easier than other vibrational spectroscopic techniques such as near infrared (NIR).
One intrinsic advantage of TRS is its excellent specificity.
Considering the unique strength of Agilent’s TRS100 in pharmaceutical analysis, I expect to see its deployment in more QC labs for product identification and assay, as well as its deployment on factory floors for real-time release testing.
This webcast describes the use of molecular spectroscopy techniques—Transmission Raman Spectroscopy (TRS) and Laser Direct Infrared (LDIR)—for solid-state analysis in pharmaceutical formulation development. In the first of two presentations, Ashish Punia from Merck & Co. will discuss “Drug Product Identification and Physical Stability Analysis by Transmission Raman based Chemometrics,” describing the significant application of transmission Raman spectroscopy in pharmaceutical drug identification and stability analysis. Darren Robey of Agilent Technologies will then present “Advances in Chemical Imaging for Pharmaceutical Formulation Development using Laser Based Infrared Spectroscopy,” focusing on fast chemical imaging of tablet surfaces by LDIR.
Analytical method development using transmission Raman spectroscopy for pharmaceutical assays and compliance with regulatory guidelines—Part II: Practical Implementation Considerations, B. Igne et al., J. Pharm. Innov., 14 2019 了解更多信息