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Applications
Automating Dissolution Testing with an Agilent Online LC System (PDF)

In this application note, an Agilent InfinityLab Online LC system was coupled with the Agilent Flexible Cube to enable fully automated,unattended, real-time dissolution testing. The automatic sample delivery and multiple sample point switching...

  • Publication Part Number: 5994-7502EN
  • Created: 09 Oct 2024
  • 968 KB
  • PDF
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Applications
Entire Workflow from Dissolution Sampling, LIMS, HPLC Measurement to Result (PDF)

Analysis of dissolution samples by HDR HPLC detection and a barcode sample ID workflow

  • Publication Part Number: 5994-8138EN
  • Created: 17 Feb 2025
  • 633 KB
  • PDF
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General Article
Core Applications of UV Dissolution Software

Agilent s UV Dissolution System software gives you real-time results, reduces analyst time and effort, and shortens decision timelines for critical projects.

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Webinar
The Dissolution Method Transfer Series - Session 1 - Building a Robust Dissolution Method (PDF)

Focuses on ensuring that the dissolution method is robust and able to be validated and transferred

  • Created: 11 July 2014
  • 2 MB
  • PDF
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Webinar
Fiberoptic UV Dissolution Method Development (PDF)

Fiberoptic UV Dissolution Method Development

  • Created: 11 July 2014
  • 841 KB
  • PDF
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Webinar
The Dissolution Method Transfer Series - Session 2: Validating dissolution methods (PDF)

Dissolution validation will be presented in a step by step process to minimize time spent in this activity and to make sure that the method is fully challenged.

  • Created: 11 July 2014
  • 445 KB
  • PDF
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Webinar
The Dissolution Method Transfer Series Session 3 Transferring Dissolution Methods (PDF)

Discusses identifying potential changes to the dissolution process and how to properly address them for a successful transfer.

  • Created: 11 July 2014
  • 845 KB
  • PDF
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Webinar
Validation of a Semi-Automated Dissolution Method (PDF)

Dissolution

  • Created: 30 May 2013
  • 2 MB
  • PDF
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Training
DISS-0GEN-2091e - The Verification of Automated Dissolution Methods

Overview of the Verification of Automated Dissolution Methods in the cGMP compliant pharmaceutical laboratory. This course may be accessed unlimited times over a 90-day period.

  • Course Number: DISS-0GEN-2091e
  • Course Length: 0.7 Hour(s)
  • Course Type: Self-Paced eLearning
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Training
DISS-0GEN-2090e - Dissolution and the Analytical Method Transfer

Overview of the Dissolution and the Analytical Method Transfer in the cGMP compliant pharmaceutical laboratory. This course may be accessed over a 90-day period.

  • Course Number: DISS-0GEN-2090e
  • Course Length: 0.7 Hour(s)
  • Course Type: Self-Paced eLearning
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Quick Reference
Dissolution FAQ: Filters (PDF)

Frequently asked question for dissolution filters.

  • Created: 18 Dec 2012
  • 19 KB
  • PDF
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Dissolution Qualification

Agilent’s calibration and verification systems for dissolution applications help analysts in labs all over the world to qualify their dissolution testers. The 280-DS mechanical qualification system (MQS) provides unique qualification technology...

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Dissolution Autosamplers

Accurate and reproducible sampling is the cornerstone of a productive dissolution workflow. Our automated dissolution sampling systems, such as the 850-DS, boost the efficiency of applications by increasing throughput. The 850-DS is an integrated...

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Dissolution Paddles, Baskets & Sinkers

Customize your Agilent dissolution instrument with interchangeable dissolution accessory components including spin on/off shafts and paddles, a variety of baskets, or sinkers for Apparatus 1 and 2 methods.

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Dissolution Reciprocating Accessories

Agilent provides a variety of reciprocating cylinders and holders for Apparatus 3 and 7 dissolution instruments.

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Paddle over Disk & Rotating Cylinder

The paddle over disk assembly and the rotating cylinder are used for the dissolution testing of transdermal patches with a standard dissolution apparatus, such as the 708-DS. These accessories comply with Apparatus 5 and 6 methods.

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Dissolution Workstation Software

Software control of dissolution apparatus and automated sampling components.

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Agilent Dissolution Workstation Software offers data integrity and automation to analysts using USP dissolution apparatus. Dissolution Workstation Software helps laboratory managers achieve secure and controlled access to methods and dissolution apparatus.|Specific access can be granted to different laboratory analysts with Dissolution Workstation Software. All user changes are tracked and electronically recorded. Secure tracking of what was done, when, and how, with all changes, facilitates 21 CFR Part 11 compliance for the regulated laboratory environment.|Dissolution Workstation Software is ideal for busy laboratory managers responsible for testing drug dosage forms like tablets, gels, capsules, and long-acting injectables. All method parameters, instrument parameters, plus accessory information and test data are captured and recorded.|This Dissolution Software lets you build, edit, search, retrieve, and archive all dissolution apparatus methods and dissolution accessories from a single interface. Laboratories testing generic drugs and branded pharmaceutical products use Dissolution Workstation Software for both efficient operation and data integrity.

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1260 Infinity II High-Temperature GPC System

HT-GPC System for reproducible characterization of any polymer at high temperatures up to 220 °C.

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The 1260 Infinity II High-Temperature GPC System (HT-GPC) can provide information about all of today’s engineering polymers such as polyolefins, which are one of the most popular polymers with numerous applications. This level of detail helps with development and to predict how a given batch will process and perform in the final product.|Traditionally challenging materials such as polyethylene and polyamides can be analyzed routinely regardless of detection technique. High-temperature light scattering, viscometry, and concentration detectors (RID and HTELSD) all deliver a wealth of information, whatever your polymer of interest.
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Cary 60 Multicell UV Dissolution System

Single or dual apparatus configurations

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The Cary 60 UV-Vis spectrophotometer with multicell changer incorporates a Xenon lamp to take samples simultaneously and read each one sequentially. Each vessel has a dedicated flow cell and tubing, eliminating cross-contamination.|Cary WinUV dissolution software is designed to be used in a 21 CFR Part 11 environment. When used in a dual-apparatus configuration, each apparatus can run independent methods and analysts can easily customize final reports with a complete summary of the data acquisition using comparison and statistical evaluation tools, data tables, and dissolution profiles.
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Dissolution Paddles

Dissolution paddles that are available in stainless steel, DLC-coated, PTFE-coated, or PEEK in a range of standard, or mini sizes.

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In paddle dissolution method, dissolution paddles are attached vertically at the end of a rotating shaft to release the active pharmaceutical ingredient from the dosage form inside the holding vessel. Agilent dissolution rotating paddles are compatible with both apparatus 2 and apparatus 5 methods.|Agilent apparatus 2 paddles are available in a variety of inert materials for different sample matrices, including stainless steel, DLC-coated, PTFE-coated, and PEEK. The 2-piece spin on/off shaft design in combination with a fixed installed upper receptor shaft, enables fast and easy interchange between dissolution paddles and basket shafts. It further eliminates long lasting shaft length verification process. Different shaft lengths and paddle sizes are offered to provide solutions for vessel volumes of 100/200 mL, 250 mL, 1L and 2L. Paddles for the Agilent 708-DS instrument and legacy Varian and VanKel instrumentation are available.|All Agilent USP apparatus 2 & 5 paddles are serialized and designed to meet USP specifications including an individual CoC as standard.

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