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1260 Infinity II High-Temperature GPC System

HT-GPC System for reproducible characterization of any polymer at high temperatures up to 220 °C.

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The 1260 Infinity II High-Temperature GPC System (HT-GPC) can provide information about all of today’s engineering polymers such as polyolefins, which are one of the most popular polymers with numerous applications. This level of detail helps with development and to predict how a given batch will process and perform in the final product.|Traditionally challenging materials such as polyethylene and polyamides can be analyzed routinely regardless of detection technique. High-temperature light scattering, viscometry, and concentration detectors (RID and HTELSD) all deliver a wealth of information, whatever your polymer of interest.

NanoDis System

Accurate release profiles of APIs utilizing conventional dissolution apparatus.

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The Agilent NanoDis System provides formulation scientists with accurate release profiles of APIs using conventional dissolution test apparatus in an automated, compliant manner. This functionality enables dissolution analysts to uncover the best nanoparticle formulation faster, and achieve accurate and reliable results in any dissolution tests for tablets or liposome drug products.|Looking for dissolution test apparatus that can get your products to market faster? Easily transition from R&D to QC environments and achieve consistent, reliable results for nanoparticle dissolution testing in an automated process while ensuring cGMP compliance.

Cary 60 Fiber Optic UV Dissolution System

In situ fiber optic measurement

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Agilent's Cary 60 fiber optic (FO) UV dissolution system is an ideal choice for analyzing dosage forms where speed is essential. With a xenon lamp and the ability to sample as often as every 45 seconds, the Cary 60 UV-Vis spectrophotometer with an FO multiplexer provides precise and accurate determination of dissolution concentration.|Available in single- or dual-apparatus configurations, the system offers in situ readings that eliminate the need for pumps and the movement of media. Because probes are only lowered into position when a sample is taken, hydrodynamic disturbance is minimized.

Dissolution Workflow Manager for OpenLab CDS

OpenLab software platform to manage complete dissolution workflows in regulatory compliant labs.

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The Dissolution Workflow Manager (DWM) is an easy-to-install software plug-in for OpenLab CDS. This software offers flexibility, data integrity, and 21 CFR Part 11 compliance with a clear digital audit trail. User-level permissions and privileges can be regulated in this dissolution software.|Dissolution Workflow Manager is best for managing the end-to-end workflow of dissolution testing involving USP apparatus 1,2,5, and 6. This dissolution testing software can perform multiple functions, ranging from automated dosage delivery, sampling, and filtration to system cleaning. Real-time dissolution test status and key dissolution testing parameters can be tracked live during the test.|After the dissolution test, analysts can create and store digitally signed reports with all key details. Any changes in methods, instrument configurations, or users are digitally tracked. DWM for OpenLab CDS is ideal for pharmaceutical QC and R&D labs that require efficiency with data integrity.

Dissolution Baskets

USP stainless steel 40-mesh baskets, Agilent dissolution baskets with varying meshes for small and large dosage forms to perform dissolution apparatus basket tests.

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Dissolution baskets are cylindrical baskets that contain dosage forms and are placed at the end of the rotating shafts for dissolution apparatus 1 or reciprocating apparatus 7 holders. Agilent offers dissolution apparatus baskets that are constructed from non-reactive mesh to ensure accuracy of testing results. From the standard USP stainless steel 40-mesh basket, to Agilent dissolution baskets with varying mesh sizes (e.g. 20-mesh baskets, 10- mesh baskets), to baskets specific to small or large dosage forms, Agilent supports your needs. Inert PTFE or gold coatings for dissolution baskets are available to avoid API adsorption on stainless steel surfaces.|Unless otherwise noted, all of our dissolution baskets fit the standard basket shafts to perform dissolution apparatus basket tests.

400-DS Apparatus 7

Testing of small-volume novel dosage forms such as combination products like drug-eluting stents.

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The Agilent 400-DS Apparatus 7 is an instrument that enables simultaneous, small volume dissolution testing of up to 13 samples. The 400-DS is designed for testing novel dosage forms, allowing users to carry out combination products dissolution testing and evaluations. The innovative design incorporates both the dissolution apparatus and the autosampler.|Operated by software designed to comply with 21 CFR Part 11 guidelines, the 400-DS Apparatus 7 offers convenience, increased throughput, and efficiency to your QC and R&D operations. The system can be customized to your needs to hold drug-eluting stents, pacemaker leads, medicated contact lenses, catheters, and more.

Applications

Dissolution of a PLGA Nanoparticle Formulation Using the Agilent NanoDis System (PDF)

PLGA nanocapsules loaded with all-trans retinoic acid(RA) characterized using the Agilent NanoDis system were compared to a release profile using a dialysis technique.

Publication Part Number: 5994-5536EN
Created: 09 Dec 2022
280 KB
PDF

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Chinese (Simplified) (China)	Complete (PDF)

Applications

Dissolution of an Immediate Release Nanoparticle Formulation Using the Agilent NanoDis System (PDF)

Dissolution profiles of Ibuprofen nanoparticles are investigated using the Agilent NanoDis system for accurate performance testing of drug formulations.

Publication Part Number: 5994-5537EN
Created: 09 Dec 2022
363 KB
PDF

Supporting Documents

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Chinese (Simplified) (China)	Complete (PDF)

Applications

Dissolution of a Propofol Liposomal Formulation Using the Agilent NanoDis System (PDF)

The Agilent NanoDis system is utilized to investigate the effects of dissolution medium on drug release rate.

Publication Part Number: 5994-5538EN
Created: 09 Dec 2022
248 KB
PDF

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User Manuals

8020 Operator's Manual 70-9061 (PDF)

8020 Operator's Manual 70-9061

Created: 13 July 2019
1 MB
PDF

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Technical Overviews

Agilent 280-DS Mechanical Qualification System for Dissolution Apparatus 1 and 2 (PDF)

280-DS MQS, a user friendly system with Software bulit for 21 CFR part 11 Compliance.

Publication Part Number: 5991-7007EN
Created: 01 July 2016
1 MB
PDF

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Technical Overviews

Agilent Vacuum-Formed (VF) Molded Dissolution Vessels (PDF)

As the transition to enhanced MQ continues to gain traction throughout the industry, these vessels fill a void created by not performing the USP PVT) using Prednisone tablets.

Publication Part Number: 5991-2786EN
Created: 30 July 2013
823 KB
PDF

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User Manuals

BIO-DIS Apparatus 3 / 7 Operator's Manual 70-9057 (PDF)

BIO-DIS Apparatus 3 / 7 Operator's Manual 70-9057

Publication Part Number: 70-9057
Created: 09 Nov 2022
2 MB
PDF

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Brochures

Setting the Standard for Small-Volume Drug-Release Testing (PDF)

Agilent 400-DS Apparatus 7

Publication Part Number: 5994-1901EN
Created: 30 Mar 2020
953 KB
PDF

Supporting Documents

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Portuguese (Brazil)	Complete (PDF)
Spanish (Spain)	Complete (PDF)
Italian (Italy)	Complete (PDF)
Japanese (Japan)	Complete (PDF)
French (France)	Complete (PDF)