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Dissolution Cannula Filters

Color-coded Agilent Full Flow Filters (dissolution cannula filters) prevents tubing clogging and consistent test results.

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Cannula filters are a type of dissolution filters that fit on the end of dissolution cannulas and provide filtration when sampling occurs. Agilent Full Flow Filters, where the whole construction of the dissolution cannula filter is made from filter material, offer an increased surface area for filtration. The large surface area greatly increases the filtration capacity and prevents clogging. |Agilent Full Flow Filters are made of either ultrahigh molecular weight polyethylene (UHMWPE) or the polyvinylidene fluoride (PVDF). These dissolution cannula filters are relatively inert and can be used for different sample matrices. PVDF cannula filters are available in those instances where chemical compatibility or sample adsorption is an issue with UHMWPE. These are made of a low protein-binding material that can filter a wide variety of active drug substances. Both UHMWPE and PVDF cannula filters can be used with dissolution cannulas and are available in packs of 100 or 1000.

Dissolution Fittings & Accessories

Replacement tubing fittings to connect a dissolution tester to a sampling instrument.

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Sampling and manifold replacement tubing fittings are available to connect an Agilent dissolution tester to a sampling instrument such as the 850-DS dissolution sampling station.

Dissolution Sampling Cannulas

Available in two different lengths based on the volume of media; best used with full flow filters.

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The Agilent cannula luer lock assembly is comprised of a bent cannula and a sampling syringe that are best used with the full flow filters. The sampling cannulas are available in two different lengths based on the volume of media being sampled from.

Dissolution Conversion Kits

Agilent can also support small-volume dissolution with the 708-DS dissolution apparatus.

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The Agilent 708-DS dissolution apparatus can also support small-volume dissolution. Each position will require a conversion kit to hold a 100 or 200 mL vessel in position. The conversion kits are designed to be used with either mini paddles, mini baskets, or enhancer cells.

Dissolution Paddles

Dissolution paddles that are available in stainless steel, DLC-coated, PTFE-coated, or PEEK in a range of standard, or mini sizes.

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In paddle dissolution method, dissolution paddles are attached vertically at the end of a rotating shaft to release the active pharmaceutical ingredient from the dosage form inside the holding vessel. Agilent dissolution rotating paddles are compatible with both apparatus 2 and apparatus 5 methods.|Agilent apparatus 2 paddles are available in a variety of inert materials for different sample matrices, including stainless steel, DLC-coated, PTFE-coated, and PEEK. The 2-piece spin on/off shaft design in combination with a fixed installed upper receptor shaft, enables fast and easy interchange between dissolution paddles and basket shafts. It further eliminates long lasting shaft length verification process. Different shaft lengths and paddle sizes are offered to provide solutions for vessel volumes of 100/200 mL, 250 mL, 1L and 2L. Paddles for the Agilent 708-DS instrument and legacy Varian and VanKel instrumentation are available.|All Agilent USP apparatus 2 & 5 paddles are serialized and designed to meet USP specifications including an individual CoC as standard.

Dissolution Shafts

Shafts of different materials and lengths, individually serialized to meet standard USP design.

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Agilent provides stainless steel, PTFE-coated, gold-plated, or mini shafts that are individually serialized. Several basket and paddle shaft lengths and options are available to meet standard USP design.

Dissolution Evaporation Covers

A variety of evaporation covers are available to fit your apparatus and vessels.

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A variety of evaporation covers are available to fit your apparatus and vessels. Evaporation plugs are used to minimize evaporation by sealing unused ports in the evaporation covers.

Dissolution Baskets

USP stainless steel 40-mesh baskets, Agilent dissolution baskets with varying meshes for small and large dosage forms to perform dissolution apparatus basket tests.

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Dissolution baskets are cylindrical baskets that contain dosage forms and are placed at the end of the rotating shafts for dissolution apparatus 1 or reciprocating apparatus 7 holders. Agilent offers dissolution apparatus baskets that are constructed from non-reactive mesh to ensure accuracy of testing results. From the standard USP stainless steel 40-mesh basket, to Agilent dissolution baskets with varying mesh sizes (e.g. 20-mesh baskets, 10- mesh baskets), to baskets specific to small or large dosage forms, Agilent supports your needs. Inert PTFE or gold coatings for dissolution baskets are available to avoid API adsorption on stainless steel surfaces.|Unless otherwise noted, all of our dissolution baskets fit the standard basket shafts to perform dissolution apparatus basket tests.

Dissolution Workstation Software

Software control of dissolution apparatus and automated sampling components.

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Agilent Dissolution Workstation Software offers data integrity and automation to analysts using USP dissolution apparatus. Dissolution Workstation Software helps laboratory managers achieve secure and controlled access to methods and dissolution apparatus.|Specific access can be granted to different laboratory analysts with Dissolution Workstation Software. All user changes are tracked and electronically recorded. Secure tracking of what was done, when, and how, with all changes, facilitates 21 CFR Part 11 compliance for the regulated laboratory environment.|Dissolution Workstation Software is ideal for busy laboratory managers responsible for testing drug dosage forms like tablets, gels, capsules, and long-acting injectables. All method parameters, instrument parameters, plus accessory information and test data are captured and recorded.|This Dissolution Software lets you build, edit, search, retrieve, and archive all dissolution apparatus methods and dissolution accessories from a single interface. Laboratories testing generic drugs and branded pharmaceutical products use Dissolution Workstation Software for both efficient operation and data integrity.

Dissolution Flow Cells

Flow cells for the Cary UV-Vis spectrophotometers integrate dissolution testing with online UV.

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Flow cells for the Agilent Cary UV-visible spectrophotometer help integrate dissolution testing with online UV analysis to provide a single-source, automated, performance-testing solution.

Dissolution Vials, Tubes & Trays

Sampling vials, tubes, and trays for the 850-DS dissolution sampling station and 400-DS apparatus 7.

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Agilent provides a variety of sampling vials, tubes, and trays for the 850-DS sampling station and 400-DS apparatus 7.

Dissolution Racks & Rinse Trays

Dissolution storage racks and rinse trays are available to store and clean your accessories.

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Dissolution storage racks are available for one-piece or two-piece interchangeable paddles. Rinse trays are useful tools to clean your accessories easily.

Dissolution UV Probes

Interchangeable, with pathlengths from 1 to 20 mm to accommodate a variety of sample concentrations.

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The Cary 60 spectrophotometer probes use silica fibers for optimal performance, and interchangeable probe tips make cleaning and replacement cost-efficient and easy. Tip pathlengths from 1 to 20 mm are available to accommodate a wide variety of sample concentrations.

Dissolution Vessels

Dissolution vessels for Agilent Instruments, including Varian and Vankel, and in different sizes or forms (Peak vessels).

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Dissolution vessels are used to hold dissolution media during drug release.
Agilent provides a variety of dissolution vessels for use with Agilent dissolution apparatus. Selected verified vessels are available containing a Certificate of Conformance (COC).|TruAlign vessels for the 708-DS are serialized and have a collar incorporated on the vessel to maintain accurate centering, reproducible vessel orientation, and verticality alignment. TruCenter and EaseAlign vessels are available for legacy Agilent 705-DS, VK7000/10 and V-series dissolution apparatus.|Beside clear glass standard vessels, low actinic red vessels (similar to amber vessels) are offered to protect light sensitive dosage forms. Dissolution peak vessels (Apex vessels) are available to avoid coning in dissolution.|Molded vessels are vacuum formed (VF) and offer the tightest precision available to reduce position-to-position variability and improve uniformity. Unlike standard vessels that can be inconsistent in cylindricity, roundness, and concentricity, the molded VF vessels meet stringent specifications and allow you to focus on testing your dosage form rather than worry about your vessel parameters.

Dissolution Sinkers

A variety of dissolution sinkers are available depending on your dosage form.

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Capsule wire, weights, and sinker baskets are used to retain a solid dosage form at the bottom of the vessel for testing when the dosage form is buoyant. Depending on your dosage form, a variety of options are available.

Dissolution Workflow Manager for OpenLab CDS

OpenLab software platform to manage complete dissolution workflows in regulatory compliant labs.

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The Dissolution Workflow Manager (DWM) is an easy-to-install software plug-in for OpenLab CDS. This software offers flexibility, data integrity, and 21 CFR Part 11 compliance with a clear digital audit trail. User-level permissions and privileges can be regulated in this dissolution software.|Dissolution Workflow Manager is best for managing the end-to-end workflow of dissolution testing involving USP apparatus 1,2,5, and 6. This dissolution testing software can perform multiple functions, ranging from automated dosage delivery, sampling, and filtration to system cleaning. Real-time dissolution test status and key dissolution testing parameters can be tracked live during the test.|After the dissolution test, analysts can create and store digitally signed reports with all key details. Any changes in methods, instrument configurations, or users are digitally tracked. DWM for OpenLab CDS is ideal for pharmaceutical QC and R&D labs that require efficiency with data integrity.

Dissolution Verification Tools

A variety of different height gauges and spacers to meet all needed regulatory specifications.

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Verification and calibration tools can help you to install your accessories properly. Agilent provides a variety of different height gauges and spacers to meet all needed regulatory specifications, such as mechanical qualification and physical parameter verification, for your dissolution test.

Dissolution Tubing & Tubing Kits

Replacement tubing and tubing kits to connect a dissolution to a sampling instrument.

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Sampling and manifold replacement tubing and tubing kits are available to connect an Agilent dissolution tester to a sampling instrument such as the 850-DS dissolution sampling station. These tubings should be replaced on a regular basis.

Dissolution Enhancer Cells

The Enhancer (immersion) Cell is a PTFE cell with adjustable volume and a retaining cap.

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The Enhancer (immersion) Cell is a PTFE cell with adjustable volume and a retaining cap to eliminate air pockets trapped against the skin or artificial membrane that provide the diffusion barrier.

Dissolution Centering Rings

Centering rings are available in various types and sizes.

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The correct positioning of vessels is critical for dissolution testing. Some dissolution vessels are held in place by a centering ring, which are available in various types and sizes.