GPC/SEC Analysis with Conventional Calibration

Name: GPC/SEC Analysis with Conventional Calibration
Brand: Agilent
SKU: PRDT_3622140

gpc-analysis-ri-detection

Trusted GPC/SEC analysis for routine characterization

GPC/SEC is a widely applied technique to provide molar mass distributions and averages for macromolecular samples, allowing for easy and reliable sample comparison. In GPC/SEC, the sample components are chromatographically separated based on their size, and the elution volume is correlated to molar mass using appropriate standards of known molar mass. Agilent specialists will perform contract analysis on your macromolecular samples using conventional GPC/SEC, selecting chromatographic conditions suitable for your samples and specific analytical needs

GPC/SEC analysis of your samples using suitable chromatographic conditions, selected either by you or our specialists
Large portfolio of applicable calibration standards
Determination of molar mass averages and distributions relative to well-characterized standards
Calibration using broadly distributed standards or cumulative match calibration, available on request
Analysis report listing all relevant parameters, including documentation of the sample preparation
Customer-defined multi-area calculations, available on request
Besides RI detection, UV, ELSD, or fluorescence detection are provided on request
Slice lists, available on request

Features

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How it works

How to submit a sample for conventional GPC/SEC calibration

In order to have our specialists perform analysis of your GPC/SEC and macromolecular samples for conventional GPC/SEC calibration, you will need to submit them to us. There is a simple process to follow when sending your samples to us, as well as a few sample requirements. More information on how to submit samples can be found here.

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Applications

Good/bad sample comparison in molar mass distributions

Undesirable changes in GPC/SEC and macromolecular application properties can result from unrecognized alterations in molar mass and molar mass distributions. An easy way to identify such issues is a comparison of the GPC/SEC chromatogram of the badly behaving material with well-behaving material.

Quality control and optimization of processing conditions

Changes in molar mass and molar mass distribution can impact application properties of macromolecules. Therefore, molar mass control is essential. GPC/SEC with RI detection is the ideal workhorse when it comes to molar mass characterization of macromolecules. As GPC/SEC provides information on the whole molar mass distribution, it provides more detailed information than a simple molar mass average. The molar masses can be easily compared to the specifications to identify out-of-spec materials.

Unsuitable processing conditions can result in undesirable polymer degradation or branching/cross-linking reactions of macromolecules, which might impact product quality. Such changes in molar mass distribution are easily determined by GPC/SEC analysis, allowing the optimization of processing conditions.

Identifying effects of synthesis conditions on molar mass

Polymer properties can be adjusted by changing molar mass and molar mass distribution. The amount of initiator used, concentration, temperature, feeding rate, and so on, are parameters affecting molar mass and molar mass distribution. GPC/SEC allows investigation of the effects of synthesis conditions on molar mass, allowing the identification of suitable conditions to achieve the desired properties.

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Documents & support: learn, troubleshoot & train

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Tools

LC Application Finder

Search for GPC/SEC Application Notes and Technical Overviews

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News

Expanded Offerings for GPC/SEC Polymer Analysis

Agilent has acquired Polymer Standards Service GmbH (PSS), a provider of solutions for polymer characterization. PSS specializes in hardware and software solutions for gel permeation chromatography (GPC) and size exclusion chromatography (SEC). With over 35 years of expertise, they provide complete solutions for GPC/SEC applications to determine the molecular weight and size distribution of macromolecules.

Expanded Offerings for GPC/SEC Polymer Analysis / 02 Aug 2022

New Comprehensive GPC/SEC Solutions Introduced at HPLC 2023 Conference

Agilent showcased significantly expanded InfinityLab GPC/SEC Solution at the HPLC 2023 conference on June 18 – 22, 2023 in Düsseldorf, Germany. The Agilent InfinityLab GPC/SEC portfolio became even more comprehensive after the recent acquisition of Polymer Standard Service Ltd. (PSS), including a dedicated GPC/SEC Column Thermostat, a Multi-Angle Light Scattering Detector, the GPC/SEC-Ready Kit, and the powerful WinGPC Software into the already existing InfinityLab GPC/SEC Solutions for advanced material characterization.

12 Jun 2023

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Services

GPC/SEC Analysis According to Standardized Methods

On request, Agilent provides contract analysis of macromolecules based on either existing guidelines, or standards provided by our customers. We treat every sample with the highest level of care while ensuring that the analysis of your samples meets the specifications ...

GPC/SEC Analytical Services

GPC/SEC Analysis with Light Scattering/Viscosity Detection

Molar mass determination in conventional GPC/SEC is based on a comparison of the retention times of the polymer with the retention times of appropriate standards of known molar mass. For polymers where no appropriate standards are available, light scattering or viscosity ...

GPC/SEC Analytical Services

Advanced Macromolecular Characterization

New, advanced, or complexly structured macromolecules require precise, reliable, and accurate characterization. Yet, challenges in this area are faced daily in laboratories around the world. Agilent offers a variety of macromolecular analyses including deformulation analysis ...

GPC/SEC Analytical Services