Agilent AdvanceBio columns are designed to enhance the accuracy and speed of your biomolecule characterization, including monoclonal antibodies (mAbs), other proteins, peptides and synthetic oligonucleotides.
Featured Product: NEW Agilent AdvanceBio Desalting-RP cartridges
AdvanceBio Desalting-RP cartridges allow fast, efficient online removal of salt before MS detection. You can use these cartridge-style columns on their own with an Agilent 2D LC system as the second dimension to desalt collected fractions. They can also be used to perform a second-dimension desalt step after an affinity, ion exchange, or size exclusion first-dimension separation.
Topic: LabRoots webinar: Two Dimensional Liquid Chromatography Applied to the Characterization of Monoclonal Antibodies and Antibody-Drug Conjugates. Presenter: Koen Sandra, Ph.D., R&D Director Life Sciences, Research Institute for Chromatography (RIC)
Protein Identification, Impurity Profiling, and Post Translational Modifications
Reversed-phase columns to boost your accuracy and productivity
Agilent offers the most comprehensive range of optimized wide-pore, reversed-phase BioHPLC columns, all backed by technical support experts and application chemists around the globe. The family includes 1.8, 3.5, and 5 µm totally porous particles for pressures from 400 to 1200 bar; 3.5 and 5 µm Poroshell (superficially porous) particles for UHPLC separations at lower pressure, and polymeric columns for analysis under the most extreme conditions.
Ion-exchange columns to characterize charged variants with speed and confidence
Whether your goal is to characterize the next biopharmaceutical or isolate a target protein, Agilent can help you overcome the challenges of isolating and identifying charged variants of proteins. A wide range of pore sizes means you can effectively separate proteins and charged variants of any size.
Size exclusion columns for fast, high-resolution separation for affinity chromatography
Agilent BioHPLC columns for SEC are easy to integrate into your workflow, and are available in a full range of pore sizes and dimensions giving you the choices you need to perfect separations based on your analytes and method parameters.
Agilent AdvanceBio SEC Standards are uniquely designed for AdvanceBio SEC columns. The standards are manufactured from a select group of proteins and peptides optimized to deliver accurate, precise quantitation for mAb aggregation and protein analysis.
AdvanceBio Glycan Sample Preparation kit: Single part number contains reagents for deglycosylation and 2-AB labelling of the cleaved N-linked glycans, for a full consumables, single source workflow for sample preparation, columns, and standards.
Standards: Ensure consistent results with glycan standards for performance testing and retention mapping.
High-resolution oligonucleotide analysis with long column lifetime
A key challenge in the development and manufacture of oligonucleotide therapeutics is the need for analytical methods to separate and identify impurities. Agilent AdvanceBio Oligonucleotide columns and standards offer reliable high-resolution oligonucleotide analysis with long column lifetime.